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  1. 试剂
  2. 抗生素类
  • 星形孢菌素 ,98%

  • G63572 62996-74-1

    Staurosporine from Streptomyces sp

产品订购
产品货号重量货期 优惠价 数量
G63572-1mg 1mg 准现货 询价
G63572-5mg 5mg 准现货 询价
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  • 产品信息

属性

存贮条件 储存温度2-8°C
密度 1.5600
荧光 否
IC50 否
pK Values 否

描述

别名 Antibiotic AM-2282;Antibiotic AM-2282
产品介绍 Staurosporine is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM). Phase 3.
生化机理 Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively.2 However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms. The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.

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