盐酸白屈菜红碱 ,98%-3895-92-9

产品货号	规格	货期	优惠价	数量
G68742-20mg	20mg	准现货	询价

产品货号

规格

货期

优惠价

数量

G68742-20mg

20mg

准现货

询价

溶解性	Soluble in methanol, 100% ethanol, water(warm) (2 mg/ml), and DMSO (≥10 mg/ml).
存贮条件	储存温度-20°C
密度	否
荧光	否
IC50	否
pK Values	否

溶解性

Soluble in methanol, 100% ethanol, water(warm) (2 mg/ml), and DMSO (≥10 mg/ml).

存贮条件

储存温度-20°C

密度

否

荧光

否

IC50

否

pK Values

否

别名	白菜屈红碱氯化物; 白屈菜赤碱氯化物;白屈菜赤碱;1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride;Toddalin chloride
产品介绍	Chelerythrine chloride Is an isoquinoline alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae. It has been reported to be a potent and selective inhibitor of PKC (protein kinase C, IC50=0.66 μM), and an independent activator of MAPK pathways. The compound has been observed to induce apoptosis in HL-60 human promyelocytic leukemia cells. The proposed method of action of apoptotic stimulation is through the inhibition of binding BclXL to Bax or Bad at an IC50 = 1.5 μM. When used in combination with cisplatin inhibition of cell proliferation of non-small cell lung cancer cells was increased in an additive/synergistic pattern. Also through inhibition of thromboxane formation and phosphoinositide breakdown chelerythrine chloride was demonstrated to inhibit rabbit platelet aggregation and release. Chelerythrine Chloride is an inhibitor of Cox-2.
用途	A potent and selective inhibitor of protein kinase C.
生化机理	Chelerythrine affects translocation of PKC from cytosol to plasma membrane. Shown to prevent neurite growth. Induces apoptosis in a concentration- and schedule-dependent manner.

别名

白菜屈红碱氯化物; 白屈菜赤碱氯化物;白屈菜赤碱;1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride;Toddalin chloride

产品介绍

Chelerythrine chloride Is an isoquinoline alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae. It has been reported to be a potent and selective inhibitor of PKC (protein kinase C, IC50=0.66 μM), and an independent activator of MAPK pathways. The compound has been observed to induce apoptosis in HL-60 human promyelocytic leukemia cells. The proposed method of action of apoptotic stimulation is through the inhibition of binding BclXL to Bax or Bad at an IC50 = 1.5 μM. When used in combination with cisplatin inhibition of cell proliferation of non-small cell lung cancer cells was increased in an additive/synergistic pattern. Also through inhibition of thromboxane formation and phosphoinositide breakdown chelerythrine chloride was demonstrated to inhibit rabbit platelet aggregation and release. Chelerythrine Chloride is an inhibitor of Cox-2.

用途

A potent and selective inhibitor of protein kinase C.

生化机理

Chelerythrine affects translocation of PKC from cytosol to plasma membrane. Shown to prevent neurite growth. Induces apoptosis in a concentration- and schedule-dependent manner.

标识符号	GHS07
信号词	Warning
危害声明	H302-H312-H315-H319-H332-H335
警示性声明	P261-P280-P305 + P351 + P338
RIDADR	否
WGK德国	3
闪点（华氏）	N/A
RTECS	FL9200000

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