• 黄芩素 ,98%
  • W2004 491-67-8

    Baicalein

产品订购
产品货号重量货期 优惠价 数量
W2004-25g 25g 准现货 询价
W2004-1g 1g 准现货 询价
W2004-5g 5g 准现货 询价
  • 产品信息

属性

溶解性 Soluble in alcohol, methanol, ether, acetone, ethyl acetate, hot glacial acetic acid, dilute sodium hydroxide, and DMSO (50 mM). Insoluble in water
敏感性 对光和热敏感
存贮条件 储存温度2-8℃
熔点 256-271°C
密度 1.5480
荧光
IC50
pK Values

描述

别名 三羟黄酮; 黄芩苷元; 黄芩黄素; 黄芩甙元; 5,6,7-三羟基黄酮;5,6,7-Trihydroxyflavone
产品介绍 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis, that inhibits cellular Ca2+ uptake, calcium mobilization, and adjuvant-induced arthritis. Baicalein has been shown to inhibit platelet 5-LO (5-lipoxygenase) (IC50=9.5 mM) and 12-LO (12-lipoxygenases) (IC50=0.12 mM) and reverse transcriptase. Baicalein reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Baicalein is a potent anti-inflammatory and anti-tumor agent, and it blocks PREP (prolyl oligopeptidase). Baicalein induces the S-phase arrest and apoptosis in proliferation of human lung squamous carcinoma CH27 cells. The declining expression of cdk1, cdk2, cyclin D2 and cyclin A by Baicalein resulted in the G1 and G2 cell cycle arrest in C6 rat glioma cells. Baicalein has anti-thrombotic, antiproliferative and anti-mitogenic effects. Baicalein inhibits protein tyrosine kinase in leukemia (CEM) cells and PMA-stimulated PKC (protein kinase C). Baicalein is an inhibitor of 15-LO and CYP2C9.
用途 An inhibitor of Ca2+ uptake, 5-LO, and 12-LO
生化机理 中药类黄酮的组成成分,黄芩的主要黄酮,抑制花生四烯酸代谢中的12-脂肪氧化酶路径(12-lipoxygenase ,12-LOX),此路径能抑制癌细胞的增殖,诱导凋亡途径。

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