属性
存贮条件 储存温度2-8°C
描述
产品介绍 Kenpaullone是一种ATP竞争性的CDKs和GSK-3β抑制剂, 抑制 GSK-3β, CDK1/cyclin B, CDK2/cyclin A, CDK5/p25, 和 lymphocyte kinase 时, IC50值分别为0.23 μM, 0.4μM, 0.68μM, 0.85μM, 和 0.47 μM。
别名 肯帕罗酮;9-溴-7,12-二氢吲哚并[3,2-d][1]苯并氮杂卓-6(5H)-酮;HY-12302;9-Bromopaullone;NSC-664704; 9-Bromo-7,12-dihydro-indolo-[3,2-d]-[1]benzazepin-6(5H)-one
生化机理 Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC50 = 400 nM), CDK2/cyclin A (IC50 = 680 nM), CDK2/cyclin E (IC50 = 7.5 uM) and CDK5/p25 (IC50 = 850 nM).
应用 A Cdk and GKS-3 inhibitor